Poloxamer 188 improves neurologic outcome after hypothermic circulatory arrest
نویسندگان
چکیده
منابع مشابه
Neurologic Injury Following Hypothermic Circulatory Arrest
Cardiothoracic surgeons are faced with the challenge of protecting the brain during the sensitive time of interruption of normal cerebral blood flow. The brain is an exceptionally complex organ with a functional anatomy that is difficult both to understand and assess. Experimental and clinical studies have shown that the mechanism of neural injury is multifactorial. As such, discussions regardi...
متن کاملRegional low-flow perfusion improves neurologic outcome compared with deep hypothermic circulatory arrest in neonatal piglets.
BACKGROUND Regional low-flow perfusion is an alternative to deep hypothermic circulatory arrest, but whether regional low-flow perfusion improves neurologic outcome after deep hypothermic circulatory arrest in neonates remains unknown. We tested neurologic recovery after regional low-flow perfusion compared with deep hypothermic circulatory arrest in a neonatal piglet model. METHODS Sixteen n...
متن کاملModified ultrafiltration may not improve neurologic outcome following deep hypothermic circulatory arrest.
OBJECTIVE Modified ultrafiltration (MUF) improves systolic blood pressure and left ventricular performance, as well as lowering transfusion requirements, after cardiopulmonary bypass (CPB). MUF has also been shown to enhance acute cerebral metabolic recovery after deep hypothermic circulatory arrest (DHCA), but whether this improves neurologic outcome is unknown. METHODS Sixteen neonatal pigl...
متن کاملDeep hypothermic circulatory arrest.
Effective cerebral protection remains the principle concern during aortic arch surgery. Hypothermic circulatory arrest (HCA) is entrenched as the primary neuroprotection mechanism since the 70s, as it slows injury-inducing pathways by limiting cerebral metabolism. However, increases in HCA duration has been associated with poorer neurological outcomes, necessitating the adjunctive use of antegr...
متن کاملComparison of neurologic outcome after deep hypothermic circulatory arrest with alpha-stat and pH-stat cardiopulmonary bypass in newborn pigs.
OBJECTIVE Deep hypothermic circulatory arrest for neonatal heart surgery poses the risk of brain damage. Several studies suggest that pH-stat management during cardiopulmonary bypass improves neurologic outcome compared with alpha-stat management. This study compared neurologic outcome in a survival piglet model of deep hypothermic circulatory arrest between alpha-stat and pH-stat cardiopulmona...
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ژورنال
عنوان ژورنال: The Journal of Thoracic and Cardiovascular Surgery
سال: 1992
ISSN: 0022-5223
DOI: 10.1016/s0022-5223(19)34879-2